Patients with metastatic colorectal cancer (mCRC) harboring BRAF V600E mutations benefited from first-line treatment with the targeted therapies encorafenib and cetuximab plus a mFOLFOX6 chemotherapy regimen, according to results from the PhaseIII BREAKWATER trial.

Researchers firmly point the finger at the South American Andes Mountains as the place where the Irish potato famine pathogen, Phtytophthora infestans, originated.

Like a poison pen, dying cells prick their neighbors with a lethal message. This may worsen sepsis. New findings could lead to a new understanding of this dangerous illness.

A therapeutic vaccine targeting human papillomavirus type 16 (HPV16) induced regression in high-grade precancerous cervical lesions, according to the results from a phase II clinical trial.

A research team has identified the core gene expression networks regulated by key proteins that fundamentally drive phenomena such as cancer development, metastasis, tissue differentiation from stem cells, and neural activation processes.

According to a recent study, the tendency to experience positive affectivity contributed to people being physically active or even increasing their activity during the COVID-19 restrictions. In contrast, depressive feelings were linked to lower physical activity. The results suggest that mental well-being can help maintain a physically active lifestyle. Mental well-being and physical activity may thus form a positive cycle.

A new study sheds light on one of the most severe consequences of stroke: damage to the brain's 'cables'-- the so-called nerve fibers -- which leads to permanent impairments.

Tissue processing advance can label proteins at the level of individual cells across whole, intact rodent brains and other large samples just as fast and uniformly as in dissociated single cells.

Various methods are used to correct errors in quantum computers. Not all operations can be implemented equally well with different correction codes. Therefore, a research team has developed a method and implemented it experimentally for the first time, with which a quantum computer can switch back and forth between two correction codes and thus perform all computing operations protected against errors.

The novel iron-based catalyst exhibits superior performance for ammonia (NH3) synthesis compared to a well-established, century-old counterpart. By designing this new catalyst with an inverse structure, they managed to boost the NH3 production rate per volume of catalyst beyond levels never reached by conventional catalysts. These findings could lead us to more efficient NH3 synthesis, which is crucial to the agricultural and chemical industries.

Researchers have demonstrated an ideal Weyl semimetal, marking a breakthrough in a decade-old problem of quantum materials.

While climate change is likely to present significant challenges to agriculture in coming decades, it could also mean that crops such as chickpeas, soyabeans and oranges are widely grown across the UK, and home-produced hummus, tofu and marmalade are a common sight on our supermarket shelves by 2080. A new study predicts that future warmer temperatures in this country would be suitable for a variety of produce such as oranges, chickpeas and okra that are traditionally grown in warmer parts of the world.

Researchers have identified an unknown family of microbes uniquely adapted to the waterlogged, low-oxygen conditions of tropical peatlands in Peru's northwestern Amazonian rainforest. The new research shows these microbes have a dual role in the carbon cycle and the potential to either moderate or intensify climate change. This process can either stabilize carbon for long-term storage or release it into the atmosphere as greenhouse gases, particularly CO2 and methane.

Scientists have developed a groundbreaking approach using specially designed peptides to improve drug formulations. This innovative method significantly enhances anti-tumor efficacy.

Researchers have used machine learning to design nano-architected materials that have the strength of carbon steel but the lightness of Styrofoam. The team describes how they made nanomaterials with properties that offer a conflicting combination of exceptional strength, light weight and customizability. The approach could benefit a wide range of industries, from automotive to aerospace.

The vestibular system is a network of organs in the inner ears that detects the motions and position of the head. The brain uses this information, along with inputs from the eyes and joints, to maintain the body's balance. Visual information has long been proven to affect balance -- for example, strobe lights and swirling images can cause instability -- but a new study shows that sounds can also be a disruptive factor for those who have vestibular hypofunction, a vestibular system disorder resulting in impaired balance.

A research team made a pivotal discovery in the field of cancer immunotherapy. The team identified a specific population of immune cells that play a critical role in successful treatment of relapsed acute myeloid leukemia (AML).

Researchers used cutting-edge X-ray techniques to gain new insights into 'infinite-layer' nickelate materials.

A research team has made significant discoveries regarding the complex reaction mechanisms of carbon dioxide (CO2) in supercritical water. These findings are crucial for understanding the molecular mechanisms of CO2 mineralization and sequestration in nature and engineering, as well as the deep carbon cycle within the Earth's interior. This understanding will help pave the way for new directions in future carbon sequestration technologies.

We're nearly one month into 2025, but if you're struggling to hold onto your New Year's resolution, stay strong, as new research shows that forming a healthy habit can take longer than you expect. Researchers found that new habits can begin forming within about two months (median of 59-66 days) but can take up to 335 days to establish.