A sweeping review of over 200 studies finds that aerobic exercises like walking and cycling offer the best pain relief and mobility gains for knee osteoarthritis. Compared to other types of exercise, aerobic training showed the strongest evidence across short- and long-term outcomes. All forms of exercise were found to be safe, but experts recommend making aerobic activity the foundation of treatment.

A major collaboration between UC San Diego and 23andMe identified genes that shape cannabis use behaviors. The study linked the CADM2 and GRM3 genes to cannabis use and connected these patterns to more than 100 traits across mental and physical health. Researchers say understanding these genetic influences could help prevent cannabis use disorder and guide future therapies.

Researchers have created a new iron supplement that merges iron, probiotics, and prebiotics. This “three-in-one” formula restores iron levels while maintaining gut health and preventing inflammation. In mice studies, it normalized hemoglobin and gut bacteria without side effects. The innovation could reshape how anemia is treated.

Groundbreaking research shows that as men age, harmful genetic mutations in sperm become more common—not just from random chance, but because some are naturally favored. Advanced sequencing revealed dozens of genes under selective pressure, many linked to serious disorders. The work reveals how evolution inside the testes can quietly shape the next generation’s genetic health.

Researchers have developed a light-emitting sugar probe that exposes how marine microbes break down complex carbohydrates. The innovative fluorescent tool allows scientists to visualize when and where sugars are degraded in the ocean. This breakthrough helps map microbial activity and carbon cycling, providing new clues about how the ocean stores and releases carbon.

A new drug combo of enzalutamide and hormone therapy has been shown to extend survival for men with recurring prostate cancer, reducing death risk by over 40%. The study followed more than 1,000 patients worldwide and was led by Cedars-Sinai researchers. Experts call it a game changer that’s likely to reshape treatment guidelines for aggressive prostate cancer.

A groundbreaking study reveals that cancer patients who received a COVID-19 mRNA vaccine within 100 days of starting immunotherapy lived dramatically longer than those who didn’t. Researchers from the University of Florida and MD Anderson Cancer Center discovered that the vaccine’s immune-activating properties may boost cancer-fighting responses, acting like a nonspecific “flare” that reawakens the immune system.

Researchers from The University of Western Australia node at the International Centre for Radio Astronomy Research (ICRAR) have uncovered a colossal bridge of neutral hydrogen gas linking two dwarf galaxies, which spans an astonishing 185,000 light-years between galaxies NGC 4532 and DDO 137, located 53 million light-years from Earth.

Mars’ north polar vortex locks its atmosphere in extreme cold and darkness, freezing out water vapor and triggering a dramatic rise in ozone. Scientists found that the lack of sunlight and moisture lets ozone build up unchecked. This discovery, made with data from ESA’s and NASA’s orbiters, could reveal clues about Mars’ past atmospheric chemistry and potential for life.

SuperAgers defy normal aging by keeping sharp memories and healthy brains well into their 80s. Northwestern scientists discovered that these individuals either resist the buildup of harmful brain proteins or remain unaffected by them. Their brains stay structurally youthful, and their strong social lives may help protect cognition. The findings could inspire new ways to delay or prevent dementia.

Researchers from NTNU and EPFL have unveiled a compact, low-cost laser that outperforms current models in speed, control, and precision. Built using microchip technology, it can be mass-produced for use in everything from Lidar navigation to gas detection. The design’s stability and easy frequency tuning could transform communication and sensing technologies.

Researchers discovered the gene that gives a rare wheat variety its unusual “triple-grain” trait. When switched on, the gene helps wheat flowers produce extra grain-bearing parts. The finding could allow scientists to grow new, high-yield crops to meet global food demand. It’s a simple genetic change with world-changing potential.

Researchers have unveiled a new model for the universe’s birth that replaces cosmic inflation with gravitational waves as the driving force behind creation. Their simulations show that gravity and quantum mechanics may alone explain the structure of the cosmos. This elegant approach challenges traditional Big Bang interpretations and revives a century-old idea rooted in Einstein’s work.

Scientists have found a new way to stop cancer growth without damaging healthy cells. Researchers from the Francis Crick Institute and Vividion Therapeutics discovered a compound that blocks the signal telling cancer cells to grow and divide. The treatment worked in mice with lung and breast tumors and didn’t cause harmful side effects seen in earlier drugs. Now entering human trials, this breakthrough could open the door to safer, more precise cancer therapies.

Both regular and “diet” soft drinks may be far worse for liver health than believed. A massive study of over 120,000 participants found that consuming more than one can a day of either sugar-sweetened or low/no-sugar beverages sharply increased the risk of metabolic-associated steatotic liver disease (MASLD) and even liver-related deaths. Surprisingly, “diet” drinks carried similar or higher risks, potentially through changes in gut bacteria and appetite regulation.

Scientists at Johns Hopkins may be closing in on dark matter’s elusive trail, uncovering a mysterious gamma ray glow at the heart of our galaxy that could signal unseen matter colliding — or perhaps the frantic spin of dying stars. Using advanced simulations that account for the Milky Way’s ancient formation, researchers found a near-perfect match between theoretical and observed gamma ray maps, tightening the link between dark matter and this puzzling energy. Yet the mystery remains: could these signals come from millisecond pulsars instead?

Researchers found that triple-negative breast cancer cells are “addicted” to lipids, a feature tied to obesity. By studying mice, they discovered that high lipid levels alone accelerate tumor growth. Lowering these fats slowed cancer progression, suggesting that lipid-lowering treatments could help. The findings also caution against high-fat diets such as keto for patients with obesity.

Weight-loss surgery dramatically outperformed GLP-1 medications in improving longevity and reducing heart, kidney, and eye complications for people with obesity and diabetes. Over 10 years, patients lost far more weight and required fewer medications. Experts say surgery continues to offer survival advantages even in the age of potent obesity drugs.

Stanford scientists have solved a long-standing challenge in growing brain organoids by using a simple food additive to keep them from sticking together. The breakthrough enables the production of thousands of identical mini-brains at once, making large-scale testing and research possible. This leap could revolutionize how we study brain development and screen drugs for side effects. The discovery opens new paths to understanding and treating disorders such as autism and schizophrenia.

Salk Institute scientists discovered that bile acids in the liver can weaken immune cell function, making immunotherapy less effective against liver cancer. They pinpointed specific bile acids that suppress T cells and found that supplementing with UDCA reversed the effect, controlling tumor growth in mice. Since UDCA is already used for liver disease, it could quickly translate into clinical trials.