FDA has cleared an investigational new drug (IND) application to study switchable chimeric antigen receptor T cell (sCAR-T) therapy (CLBR001 + SWI019) in patients with autoimmune conditions. Patient recruitment for the phase 1 trial will begin soon (NCT06913608). The phase 1 clinical trial will evaluate the safety and efficacy of CLBR001 + SWI019 in patients with myositis, systemic sclerosis, lupus and rheumatoid arthritis, with the potential to expand to other indications in the future.

New research suggests conservation efforts could more effectively identify and protect bird species at greatest risk from climate change by better understanding the range of specific conditions they need to thrive. The study examined the relationship between the extent of the climatic conditions that species tolerate and in which populations can survive -- known as climatic niche breadth -- and their likelihood of declining in response to climate change.

New research revealed the remarkable chemical diversity of substances exuded by coral reefs and demonstrated that thousands of different chemicals derived from tropical corals and seaweeds are available for microbes to decompose and utilize.

A study has shown that Europe has adapted better to low temperatures than to high temperatures over the last two decades. The relative risk of mortality at the coldest temperatures has decreased by 2% per year since 2003, while the risk from extreme heat has only fallen by 1% per year.

New technology could enable more sustainable and cheaper production of bio-oils to replace petroleum-based products in electronic, construction and automotive applications. The technology, known as PYROCOTM, uses high temperatures without oxygen to convert treated sewage (biosolids) into a carbon-rich product called biochar, which can act as a catalyst to produce phenol-rich bio-oil.

A multi-institutional team developed a chimeric antigen receptor (CAR) T cell-based strategy for specifically targeting AML cells in patients who relapsed following other treatments. The team identified a monoclonal antibody called KG2032 that reacts with a certain variant of the HLA-DRB1 molecule. KG2032 CAR T cells displayed strong anti-AML effects in a mouse model, and CAR natural killer cells showed similar results. Clinical trials are currently being planned.

Astronomers are investigating the longest and most energetic bursts of X-rays seen from a newly awakened black hole. Watching this strange behavior unfold in real time offers a unique opportunity to learn more about these powerful events and the mysterious behavior of massive black holes.

Study reveals commonly detected environmental levels of clobazam -- a medication often prescribed for sleep disorders -- increased the river-to-sea migration success of juvenile salmon in the wild. The research team employed slow-release pharmaceutical implants and animal-tracking transmitters to monitor how exposure to clobazam and the opioid painkiller tramadol -- another common pharmaceutical pollutant -- affected the behaviour and migration of juvenile Atlantic salmon (Salmo salar) in Sweden's River Dal as they migrated to the Baltic Sea.

In a new study, researchers created an AI model of the mouse visual cortex that predicts neuronal responses to visual images.

Bird species that do well in urban areas are more colorful and less brown.

A new approach to streaming technology may significantly improve how users experience virtual reality and augmented reality environments, according to a new study. The research describes a method for directly predicting visible content in immersive 3D environments, potentially reducing bandwidth requirements by up to 7-fold while maintaining visual quality.

Researchers have explored the evolution of the genetic change that causes chronic myeloid leukaemia and show its ability to drive the disease.

Research into transcription factors deepen understanding of the 'language' of the genome, offering insights into human development.

A new study found that people with cannabis use disorder (CUD) had elevated dopamine levels in a brain region associated with psychosis.

Engineers have hit the trifecta of sustainability technology: A group has developed a low-cost method to produce carbon-free 'green' hydrogen via solar-powered electrolysis of seawater. A happy byproduct of the process? Potable water.

Wild fig tree rings offer a cheap method for tracking toxic atmospheric mercury, a byproduct of gold mining in the Global South, according to a new study.

Researchers have found a new role for the transcription factor (proteins that regulate the transcription, or copying, of genes). In the fruit fly, this transcription factor, named Traffic Jam, activates a non-coding piRNA gene named Flamenco to promote female fruit fly (drosophila) fertility. The discovery solves the 30-year-old mystery of how Flamenco gets activated to protect fruit fly ovaries from a series of genetic parasites called retroviral transposons, and may one day help with infertility issues in humans.

In a massive scientific effort, hundreds of researchers have helped to map the connections between hundreds of thousands of neurons in the mouse brain and then overlayed their firing patterns in response to visual stimuli. This breakthrough is a critical piece of foundational science to build toward understanding how our brains process visual information to reconstruct the images we see every day.

In 1962, when environmentalist and author Rachel Carson penned 'Silent Spring,' alerting the world to the dangers of the pesticide DDT, it was the reproductive threat to birds -- the bald eagle in particular -- that spurred people to action. Six decades later, researchers are taking the measure of another global environmental pollutant by drawing parallels to the crisis Carson identified. This time, the pollutant is mercury, and the sentinels are penguins living in the farthest reaches of the Antarctic Peninsula.

It's a game a lot of us played as children -- and maybe even later in life: unspooling measuring tape to see how far it would extend before bending. But to engineer, this game was an inspiration, suggesting that measuring tape could become a great material for a robotic gripper. The grippers would be a particularly good fit for agriculture applications, as their extremities are soft enough to grab fragile fruits and vegetables, researchers wrote. The devices are also low-cost and safe around humans.