A major clinical trial has delivered an unexpected twist in the search for ways to fight COVID-19 and its lingering effects. Researchers at Mass General Brigham found that taking high doses of vitamin D3 did not make COVID-19 infections less severe or reduce hospital visits. However, the study uncovered a subtle but intriguing signal suggesting that people who consistently took vitamin D supplements might be slightly less likely to develop long COVID symptoms weeks after infection.

A new study in mice suggests that a father’s nicotine exposure could influence the metabolic health of his children. Researchers found that when male mice consumed nicotine, their offspring showed changes in how their bodies handled sugar, including differences in insulin and glucose levels and altered liver function. These shifts may be linked to a higher risk of diabetes and related metabolic diseases.

Scientists studying crops irrigated with treated wastewater discovered that trace pharmaceuticals often collect in plant leaves. Tomatoes, carrots, and lettuce absorbed medications such as antidepressants and seizure drugs during the experiment. However, the edible portions of tomatoes and carrots contained much lower levels than the leaves. The findings help researchers understand how crops process contaminants as wastewater reuse becomes more common.

When the Asian financial crisis sent rice prices soaring in Indonesia in the late 1990s, the shock didn’t just strain household budgets—it left lasting marks on children’s bodies. Researchers from the University of Bonn found that kids exposed to the food price surge were more likely to experience stunted growth and, years later, a higher risk of obesity. The findings suggest that during crises, families often maintain calorie intake but cut back on nutrient-rich foods, creating hidden nutritional deficiencies that disrupt healthy development.

Researchers have created “Smart Underwear,” a wearable device that measures flatulence by detecting hydrogen produced by gut microbes. Early tests suggest people may pass gas about 32 times a day—much higher than previous estimates. The device gives scientists a new way to track gut microbial activity in everyday life. It will power a new nationwide study called the Human Flatus Atlas to map normal patterns of gas production.

Spiders and insects may not be fan favorites, but they are vital to the health of ecosystems—and scientists barely know how they’re doing. Researchers found that nearly 90% of North America’s insect and arachnid species have no conservation status, leaving their fate largely unknown. Even more striking, most states don’t protect a single arachnid species. The study warns that these overlooked creatures are essential to planetary health and urgently need better monitoring and protection.

A protein tied to ALS and dementia may have a much bigger role in disease than scientists realized. Researchers found that TDP43 controls a key DNA repair process, but when the protein becomes imbalanced, the repair system can spiral out of control, harming neurons and destabilizing DNA. The team also discovered that high levels of the protein are linked to increased mutation rates in cancer. The discovery places TDP43 at the center of both neurodegeneration and cancer biology.

Hidden in volcanic lakes and deep-sea vents, scientists have discovered tough new DNA-binding proteins built to survive extreme conditions. After scanning huge genetic databases, researchers found molecules that remain stable under heat, salt, and harsh chemistry. One of these proteins significantly improved rapid LAMP diagnostic tests, making them faster and more sensitive. The discovery could help create better tools for detecting infectious diseases.

Researchers have revealed how bacteria precisely control the genes that trigger cell division. The study shows that the MraZ protein, which normally forms a donut-shaped structure, must bend and partially break apart to bind key DNA sequences that activate division genes. Using cryo-electron microscopy, scientists captured this interaction in remarkable detail. The mechanism appears to be widespread across bacteria, offering a new window into how microbes regulate growth.

Mars didn’t always look like the barren world we see today. Over billions of years, the Sun’s solar wind stripped away much of its atmosphere, helping transform it from a warmer, wetter planet into a frozen desert. NASA’s twin-spacecraft ESCAPADE mission aims to watch this process in action by measuring how the solar wind interacts with Mars’ fragile magnetic environment. The findings could reveal how Mars lost its habitability—and help prepare humans for future missions there.

NASA’s Curiosity rover is investigating strange spiderweb-like ridges on Mars that may reveal a hidden chapter of the planet’s watery history. These “boxwork” formations likely formed when groundwater flowed through cracks in the rock, leaving minerals that hardened into ridges while surrounding material eroded away. New chemical analyses of drilled rock samples show minerals linked to water activity.

Scientists may have finally solved the mystery of strange plume-like structures hidden deep inside the Greenland ice sheet. New research suggests they form through thermal convection—slow, swirling motions driven by temperature differences inside the ice. This means the deep ice could be far softer than scientists once believed. Understanding this hidden movement could improve predictions about how Greenland’s ice sheet behaves in a warming world.

Hair may grow in a completely different way than scientists once believed. Instead of being pushed out from the root, new research shows that moving cells inside the follicle actually pull the hair upward like a microscopic motor. Advanced 3D imaging revealed a spiral movement of cells that generates this force. The finding could change how scientists study hair loss and design future treatments.

Scientists have uncovered evidence that our Sun may have traveled across the Milky Way as part of a massive migration of Sun-like stars billions of years ago. The journey may have carried the solar system away from the galaxy’s crowded center into a calmer region where life could eventually emerge.

Cambridge scientists have discovered a light-powered chemical reaction that lets researchers modify complex drug molecules at the final stages of development. Unlike traditional methods that rely on toxic chemicals and harsh conditions, the new approach uses an LED lamp to create essential carbon–carbon bonds under mild conditions. This could make drug discovery faster and more environmentally friendly. The breakthrough was uncovered unexpectedly during a failed laboratory experiment.

Scientists have uncovered an enormous hidden archive of plant DNA that has endured for more than 400 million years. By comparing hundreds of plant genomes, researchers identified more than 2.3 million regulatory DNA sequences that act like genetic switches, controlling when and how genes are activated. These sequences, known as conserved non-coding sequences (CNSs), were detected using a new computational tool called Conservatory.

A newly identified Australian tree has been dubbed the “zombie” tree because it’s alive but unable to reproduce. Myrtle rust repeatedly kills its young growth, stopping the species from flowering or making seeds. Scientists are scrambling to grow disease-free seedlings in protected locations. Their hope is that a future generation may evolve resistance and bring the species back from the brink.

Scientists have found a promising new way to manufacture one of industry’s toughest materials—tungsten carbide–cobalt—using advanced 3D printing. Normally, producing this ultra-hard material requires high-pressure processes that waste large amounts of expensive tungsten and cobalt. The new approach uses a hot-wire laser technique that softens the metals rather than fully melting them, allowing manufacturers to deposit the material only where it’s needed.

Researchers have identified two gut bacteria that can produce serotonin, a key chemical that regulates bowel movements. In experiments with mice lacking serotonin, the microbes boosted serotonin levels, increased nerve cells in the colon, and normalized intestinal movement. The study also found that people with IBS have lower levels of one of these bacteria. The discovery suggests gut microbes could become a powerful new target for treating digestive disorders.

Tiny plastic particles may be quietly threatening brain health. New research suggests microplastics—now widely found in food, water, and even household dust—could trigger inflammation and damage in the brain through multiple biological pathways. Scientists estimate adults may consume about 250 grams of these particles each year, and some can accumulate in organs including the brain.