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New scan method unveils lung function secrets

A new method of scanning lungs is able to show in real time how air moves in and out of the lungs as people take a breath in patients with asthma, chronic obstructive pulmonary disease (COPD), and patients who have received a lung transplant. It enables experts to see the functioning of transplanted lungs and could enable medics to identify sooner any decline in lung function.

Scientists discover a 'Goldilocks' zone for DNA organization, opening new doors for drug development

In a discovery that could redefine how we understand cellular resilience and adaptability, scientists have unlocked the secret interactions between a primordial inorganic polymer of phosphate known as polyphosphate (polyP), and two basic building blocks of life: DNA and the element magnesium. These components formed clusters of tiny liquid droplets -- also known as condensates -- with flexible and adaptable structures.

Fly vs. wasp: Stealing a defense move helps thwart a predator

Many flies are plagued by parasitic wasps, which lay their eggs in fly larvae, turning them into surrogate wombs for wasp larvae. One common fly has successfully fought off its wasp predator by stealing a gene from bacteria that originated in bacteriophage. Biologists inserted that gene into other flies, making these flies resistance to wasps. This discovery shows that horizontal gene transfer may be more common in animals that people thought.

Paleobiologists unlock 500,000 years of fossil records: Climate change impacts and risks of marine carbon removal

Climate change impacts not only life on land but also the largely unexplored deep-sea ecosystem, home to unique and largely unexplored fauna. Deep-sea animals, which have adapted to stable and extreme environments, are particularly vulnerable to changes in temperature and food availability. This raises a crucial question: What environmental factors are most important for deep-sea ecosystems, and how might they be disrupted?

Propranolol reduces tremors in Parkinson's disease

The standard medication levodopa does not always work against tremors in Parkinson's disease, especially in stressful situations. Propranolol, however, does work during stress, providing insight into the role of the stress system in tremors. MRI scans reveal that propranolol directly inhibits activity in the brain circuit that controls tremors. Doctors may consider this medication when levodopa is ineffective.

Researchers develop tool to fast-track measurement of protein interactions for drug discovery

Researchers have created a platform, called SIMPL2, that revolutionizes the study of protein-protein interactions by simplifying detection while improving measurement accuracy. While protein-protein interactions have previously been considered 'undruggable' using small molecules, the platform addresses this challenge by facilitating the measurement of these interactions -- improving our understanding of the types of molecules needed to control them.

Adoption of 'hospital-at-home' programs remains concentrated among larger, urban, not-for-profit and academic hospitals

Hospitals that have adopted the Center for Medicare and Medicaid (CMS) 'hospital-at-home' program, which serves as an alternative to admission to brick-and-mortar facilities, are concentrated in large, urban, not-for-profit, and academic hospitals, highlighting need for targeted incentives to expand program to smaller, rural, and non-teaching hospitals.
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