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Insights on preventing organ transplant rejection

Researchers identified a natural 'brake' within the innate immune system: the inhibitory receptor Siglec-E (SigE) and its human counterparts, Siglec-7 and Siglec-9. This receptor helps prevent overactivation of immune cells that drive rejection. When this brake is missing, inflammation worsens, leading to faster rejection in preclinical models. Importantly, transplant patients with higher levels of Siglec-7 and Siglec-9 showed better graft survival, highlighting this pathway as a promising target for new therapies.

Are you curious? It might help you stay sharp as you age

Psychology literature has shown that curiosity tends to decline with age. Psychologists shows one type of curiosity can increase well into old age, contradicting prior research. Older adults who maintain curiosity and want to learn new things relevant to their interests may be able to offset or even prevent Alzheimer's disease. Conversely, those who show muted curiosity and disinterest may be at risk for dementia.

A pipette that can activate individual neurons

Researchers have developed a new type of pipette that can deliver ions to individual neurons without affecting the sensitive extracellular milieu. Controlling the concentration of different ions can provide important insights into how individual brain cells are affected, and how cells work together. The pipette could also be used for treatments.

Groundbreaking device instantly detects dangerous street drugs, offering hope for harm reduction

Groundbreaking device instantly detects dangerous street drugs, offering hope for harm reduction A portable device that instantly detects illicit street drugs at very low concentrations, thereby highlighting the risks they pose. The device has the potential to address the growing global problem of people unknowingly taking drugs that have been mixed with undeclared substances, including synthetic opioids such as fentanyl and nitazenes.

New algorithms can help GPs predict which of their patients have undiagnosed cancer

Two new advanced predictive algorithms use information about a person's health conditions and simple blood tests to accurately predict a patient's chances of having a currently undiagnosed cancer, including hard to diagnose liver and oral cancers. The new models could revolutionize how cancer is detected in primary care, and make it easier for patients to get treatment at much earlier stages.

A 'roadmap' of the fruit fly brain

Researchers have gained comprehensive insights into the entire nervous system of the fruit fly (Drosophila melanogaster). The study describes in detail the neurons that span the entire nervous system of the adult fruit fly. The researchers also compared the complete set of neural connections (the connectome) in a female and a male specimen -- and identified differences.

The atmospheric memory that feeds billions of people: Newly discovered mechanism for monsoon rainfall

Across the globe, monsoon rainfall switches on in spring and off in autumn. Until now, this seasonal pattern was primarily understood as an immediate response to changes in solar radiation. A new study shows that the atmosphere can store moisture over extended periods, creating a physical memory effect. It allows monsoon systems to flip between two stable states. Disrupting this delicate balance, would have severe consequences for billions of people in India, Indonesia, Brazil and China.
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