Scientists have identified two specific types of brain cells that behave differently in people with depression, offering a clearer picture of what is happening inside the brain. By analyzing donated brain tissue with advanced genetic tools, the researchers found changes in neurons linked to mood and stress, as well as in immune-related microglia cells. These differences point to disruptions in key brain systems and reinforce that depression is rooted in biology, not just emotions.

A new minimally invasive procedure may help people keep weight off after stopping popular drugs like Ozempic and semaglutide—something most patients struggle with. In a clinical trial, those who underwent a technique called duodenal mucosal resurfacing regained far less weight compared to others after discontinuing the medication. The procedure works by renewing the lining of the upper small intestine, potentially “resetting” metabolism and preserving the benefits of weight loss.

Scientists at UC Irvine have found a way to potentially reverse age-related vision loss by targeting the ELOVL2 “aging gene” and restoring vital fatty acids in the retina. Their experiments in mice show that supplementing with specific polyunsaturated fatty acids—not just DHA—can restore visual function and even reverse cellular aging signs.

A breakthrough in brain-inspired computing could make today’s energy-hungry AI systems far more efficient. Researchers have engineered a new nanoelectronic device using a modified form of hafnium oxide that mimics how neurons process and store information at the same time. Unlike conventional chips that waste energy moving data back and forth, this device operates with ultra-low power—potentially slashing energy use by up to 70%.

Scientists have mapped how Earth’s deepest mantle is being deformed—and the results point to long-lost tectonic plates buried thousands of kilometers underground. Using a massive global dataset of seismic waves, they found that most deformation happens in regions where these ancient slabs are thought to reside. The findings confirm long-standing theories but, for the first time, show the pattern on a global scale. It’s a major step toward understanding how the planet’s interior slowly churns over time.

A newly discovered virus hiding inside a common gut bacterium could help explain one of medicine’s long-standing mysteries: why a microbe found in both healthy people and cancer patients is linked to colorectal cancer. The research suggests that the interaction between bacteria and the viruses they carry may be key to understanding disease risk. It may even lead to future screening tests that detect cancer risk earlier.

A bizarre crocodile relative from the age of dinosaurs is rewriting what scientists thought they knew about ancient reptiles. This poodle-sized creature, called Sonselasuchus cedrus, appears to have started life walking on all fours before shifting to a two-legged stance as it matured—an unusual transformation rarely seen in the fossil record.

A remarkably preserved, mummified reptile from 289 million years ago is rewriting what we know about how animals first breathed on land. This tiny creature, Captorhinus aguti, reveals the earliest known version of the rib-powered breathing system used by modern reptiles, birds, and mammals — a crucial innovation that helped vertebrates thrive outside water.

A new virus-fighting plastic film could transform everyday surfaces into invisible defenders against disease. Instead of relying on chemicals, this flexible material is covered in microscopic pillars that physically stretch viruses until they burst, rendering them harmless. In lab tests, it destroyed or disabled about 94% of virus particles within an hour, showing impressive effectiveness.

A routine blood marker tied to inflammation may reveal Alzheimer’s risk years in advance. Scientists found that higher neutrophil levels—part of the body’s first immune response—were linked to a greater chance of developing dementia. The discovery suggests this common lab value could help flag at-risk individuals before symptoms appear. It also raises the possibility that immune cells themselves may be fueling the disease.

Ancient DNA from a tomb near Paris reveals a shocking prehistoric reset: one population vanished and was replaced by newcomers from the south. The two groups show no genetic connection, signaling a major upheaval around 3000 BC. Disease, including early plague, likely played a role, but wasn’t the only cause. The change also reshaped society, ending tightly knit family burials and coinciding with the disappearance of Europe’s megalith builders.

Scientists have discovered unexpected water-ice clouds on a distant, Jupiter-like exoplanet, challenging current atmospheric models. By directly imaging Epsilon Indi Ab with the James Webb Space Telescope, they found less ammonia than expected—likely hidden by thick, patchy clouds. The finding reveals new layers of complexity in giant planets and shows how much we still have to learn.

A vivid green pitviper hiding in Sichuan’s misty mountains has been revealed as a completely new species. Scientists had overlooked it for decades, assuming it was a common snake—until DNA analysis proved otherwise. Named after Laozi, it features striking differences between males and females, including bold stripes and eye colors. The discovery highlights just how many unknown species may still be lurking in well-studied regions.

Scientists have discovered that combining two existing drugs can dramatically reduce liver fat linked to a common and often silent disease. The treatment not only improved liver health in animal models but also showed potential to lower heart-related risks. Interestingly, using lower doses of both drugs together worked just as well as higher doses alone. While promising, the findings still need to be tested in humans.

Scientists have uncovered a fascinating new species of pit viper in Myanmar that seems to blur the very definition of what a species is. This snake, now named the Ayeyarwady pit viper, puzzled researchers because it looks like a mix between two known species—sometimes resembling one, sometimes the other, and occasionally something in between. Initially suspected to be a hybrid, genetic analysis revealed it is actually its own distinct species.

A mysterious magnetic material once thought to host an exotic “quantum spin liquid” has turned out to be something entirely different—and possibly just as intriguing. Scientists studying cerium magnesium hexalluminate found it showed the hallmark signs of this elusive quantum state, like a lack of magnetic order and a spread of energy states. But after closer inspection using neutron experiments, they discovered the behavior came from a delicate tug-of-war between two opposing magnetic forces.

A 150-year-old rule in geometry has been proven wrong. Mathematicians found two different doughnut-shaped surfaces that look identical when measured locally but are actually different overall. For decades, researchers suspected this might be possible but couldn’t prove it—until now. The breakthrough reshapes how mathematicians understand the relationship between local measurements and global form.

Deep inside planets like Uranus and Neptune, scientists may have uncovered a bizarre new state of matter where atoms behave in unexpected ways. Advanced simulations suggest that carbon and hydrogen, under crushing pressures and scorching temperatures, can form a strange hybrid phase—part solid, part fluid—where hydrogen atoms spiral through a rigid carbon framework. This unusual “superionic” structure could reshape how heat and electricity flow inside these distant worlds, potentially helping explain their mysterious magnetic fields.

Scientists have unveiled a breakthrough imaging method that can capture the hidden details of events unfolding in trillionths of a second. This new technique doesn’t just track how bright something is—it also reveals subtle structural changes that were previously invisible, all in a single shot. By effectively turning ultrafast phenomena into detailed “movies,” researchers can now watch plasma form, electrons move, and materials transform in real time.

Scientists chasing thunderstorms in a retrofitted minivan finally captured something never seen before in nature: faint electrical glows shimmering from treetops during a storm. These “corona discharges,” long suspected but never observed outside a lab, appeared as tiny UV flashes at the tips of leaves. The discovery could reshape how we understand forests, since these bursts may help clean the air by breaking down pollutants.