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Scientists just mapped how the body rejects pig organs—and how to stop it

Scientists have achieved an unprecedented look into how the human immune system attacks a transplanted pig kidney, using spatial molecular imaging to map immune activity down to the cellular level. They discovered early signs of rejection within 10 days and pinpointed key immune players—like macrophages—driving the response. Even more exciting: when targeted therapies were applied, the immune assault weakened. As U.S. clinical trials of pig kidney transplants begin, this breakthrough offers hope for overcoming the immune barrier that has long stood in the way of xenotransplantation.

This virus infects millions—and we just discovered its secret weapon

Scientists have discovered a stealthy mechanism that cytomegalovirus (CMV)—the leading infectious cause of birth defects in the U.S.—uses to infiltrate blood vessel cells while evading immune detection. The virus forms a hidden protein complex that acts like a molecular “backdoor,” allowing it to bypass the immune system’s defenses. This newly identified pathway may explain why vaccine efforts have failed for decades and opens the door to targeted therapies that could finally prevent CMV-linked birth defects in newborns and protect vulnerable patients.

Scientists just found a sugar switch that protects your brain from Alzheimer's

Scientists have uncovered a surprising sugar-related mechanism inside brain cells that could transform how we fight Alzheimer’s and other dementias. It turns out neurons don’t just store sugar for fuel—they reroute it to power antioxidant defenses, but only if an enzyme called GlyP is active. When this sugar-clearing system is blocked, toxic tau protein builds up and accelerates brain degeneration.

Ancient DNA reveals leprosy hit the Americas long before colonization

Leprosy’s tale stretches from 5,000-year-old skeletons in Eurasia to a startling 4,000-year-old case in Chile, revealing that the rare strain Mycobacterium lepromatosis haunted the Americas millennia before Europeans arrived. Armed with cutting-edge ancient-DNA sleuthing, scientists have pieced together remarkably well-preserved genomes that challenge the idea of leprosy as purely a colonial import and hint that the disease may have homegrown American roots awaiting confirmation by future finds.

Scientists discover ‘off switch’ enzyme that could stop heart disease and diabetes

Researchers at UT Arlington have discovered a key enzyme, IDO1, that when blocked, helps immune cells regain their ability to properly process cholesterol—something that breaks down during inflammation. This breakthrough could offer a powerful new way to fight heart disease, diabetes, cancer, and more. By "turning off" this enzyme, the team restored cholesterol absorption in macrophages, potentially stopping disease at the source. Even more promising, they found a second enzyme, NOS, that makes things worse—raising hopes that targeting both could pave the way for transformative treatments for millions suffering from inflammation-driven conditions.

Fighting fire with fire: How prescribed burns reduce wildfire damage and pollution

Wildfires are becoming more intense and dangerous, but a new Stanford-led study offers hope: prescribed burns—intentionally set, controlled fires—can significantly lessen their impact. By analyzing satellite data and smoke emissions, researchers found that areas treated with prescribed burns saw wildfire severity drop by 16% and smoke pollution fall by 14%. Even more striking, the smoke from prescribed burns was just a fraction of what wildfires would have produced in the same areas.

Brain scan breakthrough reveals why Parkinson’s drugs don’t always work

Researchers are using an advanced brain imaging method called MEG to understand why Parkinson’s drug levodopa doesn’t work equally well for everyone. By mapping patients’ brain signals before and after taking the drug, they discovered that it sometimes activates the wrong brain regions, dampening its helpful effects. This breakthrough could pave the way for personalized treatment strategies, ensuring patients receive medications that target the right areas of their brain more effectively.

Scientists reveal a spontaneous reaction that could have started life

Scientists have uncovered a surprising new way that urea—an essential building block for life—could have formed on the early Earth. Instead of requiring high temperatures or complex catalysts, this process occurs naturally on the surface of tiny water droplets like those in sea spray or fog. At this boundary between air and water, a unique chemical environment allows carbon dioxide and ammonia to combine and spontaneously produce urea, without any added energy. The finding offers a compelling clue in the mystery of life’s origins and hints that nature may have used simple, everyday phenomena to spark complex biological chemistry.
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