Researchers developed a new nano-micelle formulation, CBD-IN, that finally gets CBD into the brain effectively. In mice, it relieved neuropathic pain quickly and didn’t cause the usual movement or memory side effects. Surprisingly, the pain relief didn’t use typical cannabinoid receptors, instead calming abnormal nerve activity more directly. The findings hint at new avenues for treating chronic pain and neurological diseases.

Chronic pain might quietly push people toward developing high blood pressure—and the more widespread the pain, the greater the danger. A massive analysis of over 200,000 adults uncovered strong links between long-lasting pain, depression, inflammation, and rising hypertension risk.

Scientists used CRISPR to disable the NRF2 gene, restoring chemotherapy sensitivity in lung cancer cells and slowing tumor growth. The technique worked even when only a fraction of tumor cells were edited, making it practical for real-world treatment. Since NRF2 fuels resistance in several cancers, the approach could have broad impact.

Scientists mapped the Bas63 bacteriophage in unprecedented detail, uncovering how its tail machinery infects bacteria. The structure reveals rare whisker-collar features and distant evolutionary ties reaching back billions of years. These insights could guide new phage therapies and innovations in medicine, agriculture, and industry.

Scientists at Northwestern Medicine have developed a new genetic risk score that predicts who is most likely to experience irregular or dangerous heart rhythms. The test merges several types of genetic analysis into one powerful model, offering doctors a clearer way to spot risk early. Researchers believe this “genetic roadmap” could transform how conditions like AFib are detected and prevented. It may also help shape targeted therapies tailored to a person’s unique DNA.

Scientists built a tiny clock from single-electron jumps to probe the true energy cost of quantum timekeeping. They discovered that reading the clock’s output requires vastly more energy than the clock uses to function. This measurement process also drives the irreversibility that defines time’s forward direction. The insight could push researchers to rethink how quantum devices handle information.

A new dual-light microscope lets researchers observe micro- and nanoscale activity inside living cells without using dyes. The system captures both detailed structures and tiny moving particles at once, providing a more complete view of cellular behavior. Its creators tested it by analyzing changes during cell death and were able to estimate particle size and refractive index. They hope to push the technique toward imaging particles as small as viruses.

Across the planet, animals are increasingly suffering from chronic illnesses once seen only in humans. Cats, dogs, cows, and even marine life are facing rising rates of cancer, diabetes, arthritis, and obesity — diseases tied to the same factors affecting people: genetics, pollution, poor nutrition, and stress. A new study led by scientists at the Agricultural University of Athens proposes a unified model linking these conditions across species.

Older adults who regularly listen to or play music appear to have significantly lower risks of dementia and cognitive decline. The data suggests that musical engagement could be a powerful, enjoyable tool for supporting cognitive resilience in aging.

Researchers have uncovered that SerpinB3, typically linked to severe cancers, is also a key player in natural wound healing. The protein drives skin cell movement and tissue rebuilding, especially when paired with next-generation biomaterial dressings. Its newfound role explains why cancer cells exploit it and opens the door to new wound-healing therapies.

People are more likely to believe lies when there’s the possibility of a reward. Neuroimaging shows that the brain shifts into reward or risk mode depending on whether the context involves a gain or a loss. Friends show synchronized brain activity that can predict successful deception. Social bonds and incentives can subtly warp how we judge honesty.

Ultra-processed foods, already known for their links to health problems in adults, are now shown to harm young adults too, disrupting blood sugar regulation long before illness appears. A four-year USC study following 85 participants found that even modest increases in UPF consumption drove up the risk of prediabetes and insulin resistance, two early markers that pave the way for type 2 diabetes.

Astronomers have, for the first time, recorded the moment a star’s explosion broke through its surface. The nearby supernova, SN 2024ggi, revealed a surprisingly olive-shaped blast when studied with ESO’s Very Large Telescope. The discovery helps scientists better understand the forces that drive massive stars to explode and underscores how quick international cooperation can lead to groundbreaking results.

The “Seven Sisters” have far more relatives than anyone imagined. Using NASA and ESA space telescopes, astronomers found thousands of hidden stars linked to the Pleiades, forming a colossal stellar complex. The discovery expands the cluster’s size by a factor of 20 and offers a new way to trace the shared origins of stars—including our own Sun.

Penn State scientists identified a striking rise in melanoma across several Pennsylvania counties dominated by cropland and herbicide use. The elevated risk persisted even after factoring in sunlight, suggesting an environmental influence beyond the usual expectations. Researchers warn that drifting chemicals may expose nearby residents, not just farm workers.

GLP-1 drugs like tirzepatide and semaglutide offer powerful weight-loss effects but come with unanswered questions about long-term safety, side effects, and global accessibility. Researchers stress the need for independent studies before these treatments can be fully embraced worldwide.

Electrons can freeze into strange geometric crystals and then melt back into liquid-like motion under the right quantum conditions. Researchers identified how to tune these transitions and even discovered a bizarre “pinball” state where some electrons stay locked in place while others dart around freely. Their simulations help explain how these phases form and how they might be harnessed for advanced quantum technologies.

A Princeton team built a new tantalum-silicon qubit that survives for over a millisecond, far surpassing today’s best devices. The design tackles surface defects and substrate losses that have limited transmon qubits for years. Easy to integrate into existing quantum chips, the approach could make processors like Google’s vastly more powerful.

Hawaiian short-finned pilot whales are surprisingly voracious hunters, diving hundreds of meters beneath the Pacific to snatch squid in the dark. By tagging and tracking eight whales, researchers uncovered just how much energy these deep-sea forays require—and how many squid the whales must eat to stay fueled. Their calculations reveal that each whale downs dozens to hundreds of squid per day, adding up to a staggering 88,000 tonnes of squid consumed annually by the whole population.

Researchers combined deep learning with high-resolution physics to create the first Milky Way model that tracks over 100 billion stars individually. Their AI learned how gas behaves after supernovae, removing one of the biggest computational bottlenecks in galactic modeling. The result is a simulation hundreds of times faster than current methods.