Using powerful 7-Tesla brain imaging, researchers mapped how the brainstem manages pain differently across the body. They discovered that distinct regions activate for facial versus limb pain, showing the brain’s built-in precision pain control system. The findings could lead to targeted, non-opioid treatments that use cannabinoid mechanisms instead of opioids, offering safer pain relief options.

Researchers have discovered a specific set of neurons in the amygdala that can trigger anxiety and social deficits when overactive. By restoring the excitability balance in this brain region, they successfully reversed these symptoms in mice. The results point toward targeted neural therapies for emotional disorders. This finding could reshape how anxiety and depression are treated at the circuit level.

Long-term melatonin use for sleep problems may come with unexpected heart dangers. Researchers found that chronic users were almost twice as likely to die and 3.5 times more likely to be hospitalized for heart failure. Though melatonin is widely regarded as harmless, experts now urge caution with extended use.

Long ago, some saltwater fish adapted to freshwater — and in doing so, developed an extraordinary sense of hearing rivaling our own. By examining a 67-million-year-old fossil, researchers from UC Berkeley discovered that these “otophysan” fish didn’t evolve their sensitive Weberian ear system in rivers, as long thought, but rather began developing it in the ocean before migrating inland. This new timeline suggests two separate invasions of freshwater, explaining why so many freshwater species exist today.

Researchers at McMaster University have discovered that the eyes may offer a powerful, non-invasive way to assess heart health and biological aging. By analyzing retinal scans alongside genetic and blood data from over 74,000 participants, they found that simpler, less branched eye vessels were linked to higher cardiovascular risk and faster aging.

Researchers found that embodying a digital, childlike version of one’s own face helps unlock vivid childhood memories. This illusion strengthens the connection between bodily self-perception and autobiographical recall. The findings suggest that memory retrieval is not purely mental but deeply linked to how we perceive our own bodies. Such insights could lead to tools for recovering forgotten memories or treating memory loss.

Okayama scientists have crafted a new wine grape, Muscat Shiragai, merging the wild Shiraga and Muscat of Alexandria. The variety is part of a larger collaboration between academia, industry, and local government to boost regional identity through wine. Early tastings revealed a sweet, smooth flavor, and wider cultivation is planned.

UC San Diego researchers combined artificial intelligence with molecular biology to unravel how immune cells in the gut decide between inflammation and healing, a process gone awry in Crohn’s disease. They discovered that the NOD2 gene’s interaction with a protein called girdin is crucial for maintaining balance. When this connection is lost due to a common mutation, inflammation spirals out of control.

Physicists have uncovered how direct atom-atom interactions can amplify superradiance, the collective burst of light from atoms working in sync. By incorporating quantum entanglement into their models, they reveal that these interactions can enhance energy transfer efficiency, offering new design principles for quantum batteries, sensors, and communication systems.

In the Gulf of California, a pod of orcas known as Moctezuma’s pod has developed a chillingly precise technique for hunting young great white sharks — flipping them upside down to paralyze and extract their nutrient-rich livers. The behavior, filmed and documented by marine biologists, reveals a level of intelligence and social learning that suggests cultural transmission of hunting tactics among orcas.

Boston researchers linked nighttime light exposure to greater stress-related brain activity and inflamed arteries, signaling a higher risk of heart disease. The study suggests that artificial light at night disrupts normal stress responses, leading to chronic inflammation. Experts call for reducing unnecessary light in cities and homes to protect cardiovascular health.

Researchers at UC San Diego have figured out how to get bacteria to produce xanthommatin, the pigment that lets octopuses and squids camouflage. By linking the pigment’s production to bacterial survival, they created a self-sustaining system that boosts yields dramatically. This biotechnological leap could revolutionize materials science, cosmetics, and sustainable chemistry.

Duke-NUS scientists unveiled BrainSTEM, a revolutionary single-cell map that captures the full cellular diversity of the developing human brain. The project’s focus on dopamine neurons provides crucial insight for Parkinson’s treatment. Their findings reveal flaws in current lab-grown models while offering a precise, open-source standard for future research. It’s a leap toward more accurate brain modeling and powerful cell-based therapies.

UIC researchers predict that the Sahara Desert could see up to 75% more rain by the end of this century due to rising global temperatures. Using 40 climate models, the team found widespread precipitation increases across Africa, though some regions may dry out. The results suggest a major rebalancing of the continent’s climate. Scientists stress that adaptation planning is essential to prepare for both wetter and drier futures.

Bamboo tissue paper, often marketed as an eco-friendly alternative, may not be as green as consumers think. Researchers at NC State University found that while bamboo fibers themselves are not more polluting than wood, China’s coal-dependent energy grid results in a higher carbon footprint for bamboo-based products compared to North American wood tissue. The study emphasizes that manufacturing technology and energy sources play a greater role in sustainability than the choice of fiber.

Scientists uncovered how the amino acid leucine enhances mitochondrial efficiency by preserving crucial proteins that drive energy production. By downregulating the protein SEL1L, leucine prevents unnecessary degradation and strengthens the cell’s power output. The findings link diet directly to mitochondrial health and suggest potential therapeutic applications for energy-related diseases.

Penn State scientists uncovered an ancient bacterial defense where dormant viral DNA helps bacteria fight new viral threats. The enzyme PinQ flips bacterial genes to create protective proteins that block infection. Understanding this mechanism could lead to breakthroughs in antivirals, antibiotic alternatives, and industrial microbiology.

Astronomers observed a massive, multi-temperature plasma eruption from a young Sun-like star, revealing how early solar explosions could shape planets. These fierce events may have influenced the atmosphere and life-forming chemistry of the early Earth.

A team of scientists has developed a highly accurate blood test for Chronic Fatigue Syndrome. The test reads tiny DNA patterns that reveal the biological signature of the illness. For millions who’ve faced doubt and misdiagnosis, it’s a breakthrough that finally validates their experience — and may help diagnose long Covid too.

Scientists have discovered that a “longevity gene” found in people who live beyond 100 can reverse heart aging in models of Progeria, a devastating disease that causes children to age rapidly. By introducing this supercentenarian gene into Progeria-affected cells and mice, researchers restored heart function, reduced tissue damage, and slowed aging symptoms. The discovery opens the door to new therapies inspired by the natural biology of long-lived humans—possibly reshaping how we treat both rare diseases and normal aging.