A multi-institutional team developed a chimeric antigen receptor (CAR) T cell-based strategy for specifically targeting AML cells in patients who relapsed following other treatments. The team identified a monoclonal antibody called KG2032 that reacts with a certain variant of the HLA-DRB1 molecule. KG2032 CAR T cells displayed strong anti-AML effects in a mouse model, and CAR natural killer cells showed similar results. Clinical trials are currently being planned.

Astronomers are investigating the longest and most energetic bursts of X-rays seen from a newly awakened black hole. Watching this strange behavior unfold in real time offers a unique opportunity to learn more about these powerful events and the mysterious behavior of massive black holes.

Study reveals commonly detected environmental levels of clobazam -- a medication often prescribed for sleep disorders -- increased the river-to-sea migration success of juvenile salmon in the wild. The research team employed slow-release pharmaceutical implants and animal-tracking transmitters to monitor how exposure to clobazam and the opioid painkiller tramadol -- another common pharmaceutical pollutant -- affected the behaviour and migration of juvenile Atlantic salmon (Salmo salar) in Sweden's River Dal as they migrated to the Baltic Sea.

In a new study, researchers created an AI model of the mouse visual cortex that predicts neuronal responses to visual images.

Bird species that do well in urban areas are more colorful and less brown.

A new approach to streaming technology may significantly improve how users experience virtual reality and augmented reality environments, according to a new study. The research describes a method for directly predicting visible content in immersive 3D environments, potentially reducing bandwidth requirements by up to 7-fold while maintaining visual quality.

Researchers have explored the evolution of the genetic change that causes chronic myeloid leukaemia and show its ability to drive the disease.

Research into transcription factors deepen understanding of the 'language' of the genome, offering insights into human development.

A new study found that people with cannabis use disorder (CUD) had elevated dopamine levels in a brain region associated with psychosis.

Engineers have hit the trifecta of sustainability technology: A group has developed a low-cost method to produce carbon-free 'green' hydrogen via solar-powered electrolysis of seawater. A happy byproduct of the process? Potable water.

Wild fig tree rings offer a cheap method for tracking toxic atmospheric mercury, a byproduct of gold mining in the Global South, according to a new study.

Researchers have found a new role for the transcription factor (proteins that regulate the transcription, or copying, of genes). In the fruit fly, this transcription factor, named Traffic Jam, activates a non-coding piRNA gene named Flamenco to promote female fruit fly (drosophila) fertility. The discovery solves the 30-year-old mystery of how Flamenco gets activated to protect fruit fly ovaries from a series of genetic parasites called retroviral transposons, and may one day help with infertility issues in humans.

In a massive scientific effort, hundreds of researchers have helped to map the connections between hundreds of thousands of neurons in the mouse brain and then overlayed their firing patterns in response to visual stimuli. This breakthrough is a critical piece of foundational science to build toward understanding how our brains process visual information to reconstruct the images we see every day.

In 1962, when environmentalist and author Rachel Carson penned 'Silent Spring,' alerting the world to the dangers of the pesticide DDT, it was the reproductive threat to birds -- the bald eagle in particular -- that spurred people to action. Six decades later, researchers are taking the measure of another global environmental pollutant by drawing parallels to the crisis Carson identified. This time, the pollutant is mercury, and the sentinels are penguins living in the farthest reaches of the Antarctic Peninsula.

It's a game a lot of us played as children -- and maybe even later in life: unspooling measuring tape to see how far it would extend before bending. But to engineer, this game was an inspiration, suggesting that measuring tape could become a great material for a robotic gripper. The grippers would be a particularly good fit for agriculture applications, as their extremities are soft enough to grab fragile fruits and vegetables, researchers wrote. The devices are also low-cost and safe around humans.

This handheld device is the first that can detect tuberculosis in saliva, in addition to blood and sputum samples, an important breakthrough for testing children and HIV patients, who struggle to produce sputum. The device was found to deliver rapid, accurate results in under an hour, offering a cost-effective and accessible solution for diagnosing TB in resource-limited areas.

In a new article, researchers explored whether a worker can create a psychological contract with a non-human agent in the form of an algorithm that mediates their relationship with an organization.

Researchers have identified type 5 collagen as a key factor in kidney fibrosis, revealing its potential as a biomarker to predict chronic kidney disease progression. A repurposed anti-cancer drug, Cilengitide, was found to reduce kidney scarring and slow disease progression in preclinical models, suggesting a possible precision medicine approach for high-risk patients. The team now seeks to develop a blood test to measure type 5 collagen levels, which could help identify patients at greater risk for kidney failure and guide targeted treatment strategies.

A small protein involved in neurodegeneration leading to Parkinson's disease also drives a type of skin cancer known as melanoma, according to new research.

Researchers have discovered a way to get anti-inflammatory medicine across the blood-brain barrier, opening the door to potential new therapies for a range of conditions, including Alzheimer's disease, multiple sclerosis, Parkinson's disease and cancer cachexia.