Scientists are racing to improve weight loss treatments beyond drugs like Ozempic and Wegovy, which are effective but plagued by nausea, bone loss, and weight regain. Tufts University chemists have created a new multi-target compound that goes beyond the usual GLP-1, GIP, and glucagon approaches by adding a fourth hormone, PYY. This “quadruple-action” design aims to deliver weight loss results on par with bariatric surgery—up to 30%—without invasive procedures, and could change the future of obesity treatment.

Researchers have uncovered why smell often fades early in Alzheimer’s: the brain’s immune cells dismantle key nerve connections between the olfactory bulb and brainstem. Membrane changes in neurons send an “eat-me” signal to microglia, which mistakenly destroy them. Evidence from mice, human tissue, and PET scans confirms this process. These insights could pave the way for earlier diagnosis and more effective treatment.

A single RSV vaccine dose is proving to be a powerful shield for older adults, significantly reducing hospitalizations and severe illness over two consecutive RSV seasons. While protection is strongest in the first year and declines somewhat in the second, the findings highlight both the immediate benefits and the importance of ongoing monitoring. With RSV causing tens of thousands of hospitalizations every year in the U.S., this research underscores the potential of vaccination to save lives and guide future booster strategies.

A new study projects that the Atlantic Meridional Overturning Circulation (AMOC)—the system of currents that includes the Gulf Stream—could shut down after 2100 under high-emission scenarios. This shutdown would drastically reduce heat transport northward, leaving Europe vulnerable to extreme winters, summers of drying, and shifts in tropical rainfall. Climate models show the tipping point is linked to collapsing winter convection in the North Atlantic, which weakens vertical mixing and creates a feedback loop that accelerates decline.

Sargassum has escaped the Sargasso Sea and exploded across the Atlantic, forming the massive Great Atlantic Sargassum Belt. Fueled by nutrient runoff, Amazon outflows, and climate events, these blooms now reshape ecosystems, economies, and coastlines on a staggering scale.

Young orangutans master the art of building intricate treetop nests not by instinct alone, but by closely watching their mothers and peers. Researchers tracking wild Sumatran orangutans over 17 years discovered that “peering”—the deliberate act of observing nest construction—is the key to learning.

Just 500 million years after the Big Bang, a colossal black hole, 300 million times the mass of the Sun, was already blazing at the heart of a tiny, brilliant galaxy. Found with JWST, this discovery could explain the strange "Little Red Dots" seen in the early cosmos and rewrites what we thought was possible for black hole growth.

Astronomers have taken a fresh look at the famous “Hand of God” pulsar, combining X-ray data from NASA’s Chandra Observatory with new radio observations from the Australia Telescope Compact Array. At the center is pulsar B1509-58, a rapidly spinning neutron star only about 12 miles wide that powers a nebula stretching 150 light-years across. The strange hand-shaped structure continues to surprise researchers, revealing puzzling filaments, patchy remnants, and boundaries that defy expectations.

Astronomers have found over 5,000 exoplanets, and now scientists think these distant worlds could unlock one of the universe’s greatest mysteries: dark matter. A new study suggests that Jupiter-like planets may gradually collect superheavy dark matter particles in their cores, which could one day collapse into planet-sized black holes.

Saturn’s moon Titan may be more alive with possibilities than we thought. New NASA research suggests that in Titan’s freezing methane and ethane lakes, simple molecules could naturally arrange themselves into vesicles—tiny bubble-like structures that mimic the first steps toward life. These compartments, born from splashing droplets and complex chemistry in Titan’s atmosphere, could act like primitive cell walls.

A breakthrough pill, baxdrostat, has shown remarkable success in lowering dangerously high blood pressure in patients resistant to standard treatments. In a large international trial, it cut systolic pressure by nearly 10 mmHg, enough to significantly reduce risks of heart attack, stroke, and kidney disease. The drug works by blocking excess aldosterone, a hormone that drives uncontrolled hypertension.

Beta blockers, used for decades after heart attacks, provide no benefit for patients with preserved heart function, according to the REBOOT trial. The massive study also found women faced higher risks when taking the drug. Experts say the results will change heart treatment guidelines worldwide.

A massive global study uncovered a striking paradox: even as total burned land has dropped by more than a quarter since 2002, human exposure to wildfires has skyrocketed. Africa accounts for a staggering 85% of these exposures, while California stands out as an extreme hotspot despite its relatively small share of burned land. Climate change is fueling more intense fire weather, population growth is pushing communities into fire-prone landscapes, and the overlap between people and flames is growing more dangerous.

Stanford researchers reveal meandering rivers existed long before plants, overturning textbook geology. Their findings suggest carbon-rich floodplains shaped climate for billions of years.

As the Great Salt Lake shrinks, scientists are uncovering mysterious groundwater-fed oases hidden beneath its drying lakebed. Reed-covered mounds and strange surface disturbances hint at a vast underground plumbing system that pushes fresh water up under pressure. Using advanced tools like airborne electromagnetic surveys and piezometers, researchers are mapping the hidden freshwater reserves and testing whether they could help restore fragile lakebed crusts, reduce dust pollution, and reveal long-buried secrets of the region’s hydrology.

New research suggests that exercise may not just make us feel younger—it could actually slow or even reverse the body’s molecular clock. By looking at DNA markers of aging, scientists found that structured exercise like aerobic and strength training has stronger anti-aging effects than casual activity. Evidence from both mice and humans shows measurable reductions in biological age, with benefits reaching beyond muscles to the heart, liver, fat tissue, and gut.

Drinking nitrate-rich beetroot juice lowered blood pressure in older adults by reshaping their oral microbiome, according to researchers at the University of Exeter. The study found that beneficial bacteria increased while harmful ones decreased, leading to better conversion of dietary nitrates into nitric oxide—a molecule vital for vascular health.

Scientists at Mount Sinai have created an artificial intelligence system that can predict how likely rare genetic mutations are to actually cause disease. By combining machine learning with millions of electronic health records and routine lab tests like cholesterol or kidney function, the system produces "ML penetrance" scores that place genetic risk on a spectrum rather than a simple yes/no. Some variants once thought dangerous showed little real-world impact, while others previously labeled uncertain revealed strong disease links.

Scientists have uncovered a surprising new healing mechanism in injured cells called cathartocytosis, in which cells "vomit" out their internal machinery to revert more quickly to a stem cell-like state. While this messy shortcut helps tissues regenerate faster, it also leaves behind debris that can fuel inflammation and even cancer.

Men eating ultra-processed foods gained more fat than those eating unprocessed meals, even with equal calories. Their hormone levels shifted in worrying ways, with testosterone falling and pollutants rising. Researchers say the processing itself, not overeating, is to blame.