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New cell therapy shows promising results in advanced tumor diseases

In recent years, cell therapies have developed alongside chemotherapy and immunotherapy to become a new pillar in the treatment of patients with blood and lymph gland cancer. In solid tumors, such as skin, lung, or bone and soft tissue cancer (sarcomas), they have not yet proven themselves as a treatment method. Tumor shrinkage was achieved only in rare cases, but the side effects were all the more severe. An international research group led by scientists has now succeeded in a phase 1 clinical trial in testing a novel cell therapy approach that also shows promise for solid tumors.

New way to prevent duodenal cancer

People with the hereditary disease familial adenomatous polyposis (FAP) have a greatly increased risk of developing a malignant tumor of the duodenum. Researchers have now discovered a mechanism in the local immune system that can drive the development of cancer. They see this as a promising new approach to preventing duodenal carcinoma in people with FAP.

Chimpanzee stem cells offer new insights into early embryonic development

Chimpanzee naive pluripotent stem cells (PSCs) can now be grown in cellular cultures, reveals a recent study. They successfully created chimpanzee early embryo models, called 'blastoids,' and found that the inhibition of a specific regulatory gene is essential for chimpanzee PSC self-renewal. They also developed a feeder-free culture system, eliminating the need for mouse-derived feeder cells as support. These findings provide valuable insights into primate embryology and could advance stem cell research and regenerative medicine.

This injected protein-like polymer helps tissues heal after a heart attack

Researchers have developed a new therapy that can be injected intravenously right after a heart attack to promote healing and prevent heart failure. The therapy both prompts the immune system to encourage tissue repair and promotes survival of heart muscle cells after a heart attack. Researchers tested the therapy in rats and showed that it is effective up to five weeks after injection.

Cutting the complexity from digital carpentry

Many products in the modern world are in some way fabricated using computer numerical control (CNC) machines, which use computers to automate machine operations in manufacturing. While simple in concept, the ways to instruct these machines is in reality often complex. A team of researchers has devised a system to demonstrate how to mitigate some of this complexity.

A new recycling process for silicones could greatly reduce the sector's environmental impacts

A study describes a new method of recycling silicone waste (caulk, sealants, gels, adhesives, cosmetics, etc.). It has the potential to significantly reduce the sector's environmental impacts. This is the first universal recycling process that brings any type of used silicone material back to an earlier state in its life cycle where each molecule has only one silicon atom. And there is no need for the raw materials currently used to design new silicones. Moreover, since it is chemical and not mechanical recycling, the reuse of the material can be carried out infinitely.

CMA CGM Acquires Controlling Share of Brazilian Terminal Operator


French shipping group CMA CGM reports it has closed the first stage in its planned acquisition of Santos Brasil, a multi-terminal operator in Brazil including the Port of Santos. CMA CGM announced in September 2024 its intention to acquire the company first buying shares from an institutional fund manager and then launching a tender offer for the remaining shares.

The acquisition comes as South America and specifically Brazil continues to draw investments from the major shipping companies. CMA CGM will be investing in excess of $2 billion to expand its operations in Brazil. MSC and Maersk have also announced expansions for their operations in Brazil as well as DP World.

CMA CGM reports it closed the acquisition of approximately 48 percent of the shares in Santos Brasil from funds managed by Opportunity, one of the largest asset managers in Brazil for a reported value of approximately $1.1 billion. Combined with a three percent position held by an affiliate of CMA CGM, the company now controls 51 percent of Santos Brasil.

A second stage tender will be launched for the remaining shares once an independent appraisal is completed.Β 

Santos Brasil operates five terminals and a total of eight assets, including the largest container terminal in Brazil and South America. The Tecon Santos Terminal in Santos currently has a capacity of 2.5 million TEU and will be expanded to 3 million TEU. It can dock three 14,000 TEU vessels simultaneously. Β According to CMA CGM, the terminal handles 40 percent of Brazil’s overall container volume. They also called it the most efficient terminal in the Port of Santos.Β 

The acquisition expands CMA CGM’s 20-year presence in Brazil and is keeping with the strategy to grow terminal operations and the logistics segments of the business. CMA CGM said it will support the development of Santos and the other ports and will integrate the operations with its group including CEVA Logistics.

The acquisition comes as Santos continues to report strong growth. The Port Authority reported March was the third consecutive month of increases and at 460,000 TEU was the busiest March on record. It said the positive performance resulted in an increase of nearly seven percent for the first quarter of 2025 or a total of 1.3 million TEU handed in the port.

The federal government has committed to investments in the Santos port complex. It will invest $2.2 million to improve access both by land and sea, including new roads and the deepening of the shipping channel. Β 

The Port of Santos is a key contributor to Brazil’s foreign trade accounting for nearly a third (30 percent) of the country’s trade flow in March. China is the main trading partner accounting for more than 28 percent of the volume in the port. Β In addition to containers, Santos is a major port for soybeans and other agricultural commodities as well as gasoline and the fuel sector.

Kpler Closes Spire Maritime Acquisition as UK Proceeds with Investigation


The on-again-off-again acquisition of the maritime business from Spire Global by Kpler closed on Friday, April 25, the agreed date in a settlement between the two sides, but not without a new wrinkle to the contentious combination. The UK Competition and Markets Authority (CMA) confirmed it has opened an investigation into the proposed business combination requiring the companies to be independently operated.

Kpler confirmed in the closing announcement that it is working closely with the relevant regulatory authorities and in particular with the UK Competition and Markets Authority β€œin light of their review of the transaction.” Both sides had to enter into a compliance statement with CMA promising to operate the business units separately, not sharing technology or confidential business data. In addition to not moving forward with an integration, they committed to ensure that sufficient resources are made available for the development of both businesses, on the basis of their respective pre-merger business plans and maintain their current product offerings.

Despite the latest glitch, Kpler called the closing a β€œstrategic move that bolsters Kpler's capabilities in maritime data and analytics.” Mark Cunningham, CEO of Kpler, said "The addition of this high-quality data will unlock greater value for our customers and partners by providing increasingly comprehensive and timely insights into global trade flows. It's about helping them navigate complexity, uncover opportunities, and make better decisions every day."

Spire reported the completion of the sale for approximately $233.5 million, before adjustments, plus a $7.5 million agreement for services over a twelve-month period, post-close. Spire reports it used the proceeds of the sale to retire all outstanding debt and that the remaining proceeds will be used to invest in near-term growth opportunities. It followed the terms first announced for the deal in November 2024.

Spire Global reported in February it had filed a lawsuit against Kpler for a failure to close the acquisition of its maritime group while also warning shareholders of potential debt problems if the deal is not completed. At the time, it said it believed all the conditions to closing contained in the purchase agreement had been satisfied, but that Kpler had not moved forward with the closing. Three weeks ago, Spire reported an agreement had been reached to resolve the litigation and mutually release claims, if the closing occurred by April 25.

In the CMA filing, it came out that Kpler had communicated with the regulator on February 25, March 11, March 12, March 24, March 31, and April 10, requesting that the CMA consent to derogations to the Initial Enforcement Order. CMA agreed on April 16 to permit Kpler to have a level of oversight of the acquired company while requiring that they be kept independent and Spire’s business continue as a going concern so as not to prejudice the investigation. CMA reports it is continuing to consider if the combination may be expected to result in a substantial lessening of competition in any market or markets in the United Kingdom.

Spire Maritime built its niche with real-time capabilities by designing, building, and deploying nanosatellites, each the size of a wine bottle, in a constant earth orbit collecting data from all the ships. Kpler said when the deal was announced it would expand its data reach, offering comprehensive visibility across open oceans. Management said the acquisition would further strengthen Kpler’s commitment to delivering superior real-time data and analytics to its clients, supporting informed, data-driven decision-making across the global supply chain.

Kpler in 2023 acquired MarineTraffic a portal for AIS data, mapping, and visualization along with FleetMon, a vessel database. Access to Spire Global’s proprietary satellites and analytics would enhance the portfolio.

Under the terms of the agreement, Spire Global retains its satellite network, technology, and infrastructure. It said it would focus its business on its customers in aviation, weather, and the space services sectors.
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